A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

@article{Milyavsky2010ADD,
  title={A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.},
  author={Michael Milyavsky and Olga I. Gan and Magan Trottier and Martin Komosa and Ofer Tabach and Faiyaz Notta and Eric R. Lechman and Karin G. Hermans and Kolja Eppert and Zhanna Konovalova and Olga I. Ornatsky and Eytan Domany and M Stephen Meyn and John E Dick},
  journal={Cell stem cell},
  year={2010},
  volume={7 2},
  pages={186-97}
}
Highly regenerative tissues such as blood must possess effective DNA damage responses (DDR) that balance long-term regeneration with protection from leukemogenesis. Hematopoietic stem cells (HSCs) sustain life-long blood production, yet their response to DNA damage remains largely unexplored. We report that human HSCs exhibit delayed DNA double-strand break rejoining, persistent gammaH2AX foci, and enhanced p53- and ASPP1-dependent apoptosis after gamma-radiation compared to progenitors. p53… CONTINUE READING
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