A distinct spectrum of copy number aberrations in pediatric high-grade gliomas.

  title={A distinct spectrum of copy number aberrations in pediatric high-grade gliomas.},
  author={Dorine A. Bax and Alan Mackay and Suzanne E. Little and Diana E. De Carvalho and Marta Viana-Pereira and Narinder Tamber and Anita Grigoriadis and Alan Ashworth and Rui Manuel Reis and D W Ellison and Safa Al-Sarraj and Darren Hargrave and Chris Jones Kathy Pritchard - Jones},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={16 13},
PURPOSE As genome-scale technologies begin to unravel the complexity of the equivalent tumors in adults, we can attempt detailed characterization of high-grade gliomas in children, that have until recently been lacking. Toward this end, we sought to validate and extend investigations of the differences between pediatric and adult tumors. EXPERIMENTAL DESIGN We carried out copy number profiling by array comparative genomic hybridization using a 32K bacterial artificial chromosome platform on… CONTINUE READING


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