A distinct role for secreted fibroblast growth factor-binding proteins in development

  • Krissa A. Gibbya, Kevin McDonnella, +1 author Anton Wellsteina
  • Published 2009
FGFs modulate diverse biological processes including embryonic development. Secreted FGF-binding proteins (BPs) can release FGFs from their local extracellular matrix storage, chaperone them to their cognate receptors, and thus modulate FGF signaling. Here we describe 2 chicken BP homologs (chBP) that show distinct expression peaks at embryonic days E7.5… (More)