A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

@article{Park2005ADL,
  title={A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17},
  author={Heon Park and Zhaoxia Li and Xuexian O Yang and Seon Hee Chang and Roza Nurieva and Yi-hong Wang and Ying Wang and Leroy E. Hood and Zhou Zhu and Qiang Tian and Chen Dong},
  journal={Nature Immunology},
  year={2005},
  volume={6},
  pages={1133-1141}
}
Interleukin 17 (IL-17) has been linked to autoimmune diseases, although its regulation and function have remained unclear. Here we have evaluated in vitro and in vivo the requirements for the differentiation of naive CD4 T cells into effector T helper cells that produce IL-17. This process required the costimulatory molecules CD28 and ICOS but was independent of the cytokines and transcription factors required for T helper type 1 or type 2 differentiation. Furthermore, both IL-4 and interferon… 
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo
TLDR
In the absence of IL-23, TH- 17 development was stalled at the early activation stage and fewer effector TH-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues.
Development, cytokine profile and function of human interleukin 17–producing helper T cells
TLDR
It is demonstrated that IL-23 and IL-1β induced the development of human and mouse TH-17 cells expressing IL-17A,IL-17F, IL-22, Il-26, interferon-γ, the chemokine CCL20 and transcription factor RORγt, and that human TH- 17 cells may regulate innate immunity in epithelial cells.
IL-23/IL-17 Biology and Therapeutic Considerations
  • C. Dong
  • Biology, Medicine
    Journal of immunotoxicology
  • 2008
TLDR
IL-17 and IL-17-expressing inflammatory TH lymphocytes may serve as good targets for therapeutic intervention in treatment of patients with inflammatory diseases and on the biological function of these cells in infection, autoimmunity and allergy.
gammadelta T cells: an important source of IL-17.
Distinct regulation of interleukin-17 in human T helper lymphocytes.
TLDR
The present data demonstrate the differential regulation of IL-17 and RORgammat expression in human CD4+ T cells compared with murine cells, which may have important implications in the pathogenesis of human autoimmunity as compared with mouse models.
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation
TLDR
TH-17 cells, like Treg cells, can be selected by self antigens in the thymus in a manner influenced by recognition of self antigen and by the cytokines IL-6 and transforming growth factor-β (TGF-β).
Diversity of IL-17-producing T lymphocytes
TLDR
The heterogeneity of IL-17-producing T cell types focusing on their development, regulation, and function is discussed, with particular focus on innate-like T cells.
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
TLDR
IL-21 is shown to be an autocrine cytokine that is sufficient and necessary for TH17 differentiation, and serves as a target for treating inflammatory diseases.
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