A distinct innate lymphoid cell population regulates tumor-associated T cells

  title={A distinct innate lymphoid cell population regulates tumor-associated T cells},
  author={Sarah Q. Crome and Linh Thi Thao Nguyen and Sandra L. L{\'o}pez-Verg{\`e}s and S Y Cindy Yang and Bernard Martin and Jennifer Y Yam and Dylan Johnson and Jessica Nie and Michael Pniak and Pei Hua Yen and Anca Milea and Ramlogan Sowamber and Sarah Rachel Katz and Marcus Q. Bernardini and Blaise Alexander Clarke and Patricia A. Shaw and Philipp A. Lang and Hal K. Berman and Trevor J. Pugh and Lewis L. Lanier and Pamela S Ohashi},
  journal={Nature Medicine},
Antitumor T cells are subject to multiple mechanisms of negative regulation. Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses led us to examine the regulatory potential of ILCs in the context of cancer. We identified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade serous tumors, defined their suppressive capacity in vitro, and performed a comprehensive analysis of their phenotype. Notably, the presence of this CD56… CONTINUE READING
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