A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers

@article{Lajoie2012ADC,
  title={A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers},
  author={Julie Lajoie and Jennifer A. Juno and Adam D Burgener and Shamim Rahman and Kenzie Mogk and Charles Wachihi and J Mwanjewe and Francis Allan Plummer and Joshua Kimani and Terry Blake Ball and Keith R Fowke},
  journal={Mucosal Immunology},
  year={2012},
  volume={5},
  pages={277-287}
}
The predominance of HIV-1 sexual transmission requires a greater understanding of the interaction between HIV-1 and the mucosal immune system. The study of HIV-1-exposed seronegative (HESN) individuals serves as a model to identify the correlates of protection and to aid in microbicide development. A total of 22 cytokines/chemokines were analyzed at the systemic and mucosal compartments in 57 HESN, 51 HIV-1-negative, and 67 HIV-1-infected commercial sex workers from Nairobi, Kenya. HESN… CONTINUE READING
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