A dispermic chimerism in a 2-year-old Caucasian boy

  title={A dispermic chimerism in a 2-year-old Caucasian boy},
  author={L. M. Repas-Humpe and A. Humpe and R. Lynen and B. Glock and E. Dauber and G. Simson and W. Mayr and M. K{\"o}hler and S. Eber},
  journal={Annals of Hematology},
Abstract Detection of two different cell populations in a child is a rare event. The following case of a dispermic chimera was diagnosed before surgery due to problems in blood group determination. A 2-year-old phenotypically male child was admitted for correction of a penoscrotal hypospadia and unilateral cryptorchism. During presurgical laboratory investigation, difficulties in blood group determination occurred. Blood group typing was performed by the DiaMed-ID Micro Typing System and by… Expand
A dispermic chimera was identified in a healthy man with mixed field agglutination reaction in ABO blood grouping and mosaic 46, XY/46, XX karyotype.
  • X. Hong, Y. Ying, +8 authors Li-xing Yan
  • Biology, Medicine
  • Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • 2013
A individual with dispermic chimerism was identified, which would generate by fertilization of an oocyte and the corresponding second polar body by two different sperms in a 25-year-old male. Expand
A case of 46,XX/46,XX chimerism in a phenotypically normal woman
The application of various molecular genetic testing methods was used to elucidate the chimerism observed in the proband in this study, and dispermic fertilization was suggested as the underlying mechanism. Expand
Chimerism resulting from parthenogenetic activation and dispermic fertilization
The results indicate that the chimerism in the authors' patient is the result of dispermic fertilization of a parthenogenetically activated oocyte, highlighting the difficulties in predicting the clinical outcome in patients with genetic aberrations in mosaic or chimeric form. Expand
Maternity testing in a chimerical child
Molecular analysis performed with highly discriminating STR systems allowed to clarify the origin of a chimerical individual in a case of maternity in which the alleged child has ambiguous genitalia and chimerism was suspected. Expand
A case of true hermaphroditism reveals an unusual mechanism of twinning
A rare case of 46,XX/46,XY twins: Twin A presented with ambiguous genitalia and Twin B was a phenotypically normal male, demonstrating a third, previously unreported mechanism for twinning. Expand
Chimerism and tetragametic chimerism in humans: implications in autoimmunity, allorecognition and tolerance
The genetics of chimerism and tetragametism and its potential role in thymic selection and the relevance in allotransplantation and autoimmune disorders are discussed. Expand
Chimerism in Black Southern African Patients with True Hermaphroditism 46,XX/47XY,+21 and 46,XX/46,XY
This paper represents the first report of the molecular investigation of mosiacism/chimerism as the cause of hermaphroditism in black southern African patients and is the second report worldwide of a 46,XX/47,XY,+21 chimera. Expand
Natural human chimeras: A review.
  • K. Madan
  • Medicine, Biology
  • European journal of medical genetics
  • 2020
If human chimeras are more common than hitherto thought there could be many medical, social, forensic, and legal implications, and more multidisciplinary research is required. Expand
Uniparental Disomy in Somatic Mosaicism 45,X/46,XY/46,XX Associated with Ambiguous Genitalia
The findings suggest that the observed complex DSD phenotype is the result of somatic gonosomal mosaicism and UPD despite a normal blood karyotype, and the presence of UPD warrants adequate genetic counseling for the family and frequent, lifelong, preventive follow-up controls in the patient. Expand
Chimerism in the immunohematology laboratory in the molecular biology era.
The purpose of this review was to highlight some of these chimeric states and hypothesize how testing DNA from various tissues can cause apparent discrepancies between phenotype and genotype results. Expand


Case of 46,XX/47,XY, +21 chimerism in a newborn infant with ambiguous genitalia.
We describe whole-body chimerism in a newborn infant with small phallus, pseudo-vaginal perineal hypospadias, and a bifid scrotum containing gonads. The human testis determining factor gene (SRY) wasExpand
The red cells of a normal male blood donor, K.S., were first grouped as B but he was found to lack anti‐A in his serum, leading to a suspicion of chimaerism. Expand
The Liverpool Chimaera
A dispermic human chimaera is described who is a fertile female XX/XY chimaERA discovered due to anomalies found during routine antenatal testing that had two red cell populations differing in three blood group sysems; ABO, Rh and MN. Expand
A further example of human blood group chimaerism.
Blood group chimaerism was detected in a healthy fertile woman, not known to be a twin. Her peripheral lymphocytes had a male karyotype (46/XY); fibroblasts cultured from her skin had a femaleExpand
Blood group chimaerism: a possible further example.
This case is the second example of chimaerism found within two years in a single routine laboratory, appearing to confirm the view that chimaersism is not as uncommon as previously thought. Expand
Another Example of Haemopoietic Chimaerism in Dizygotic Twins
The biological significance of these findings is discussed with special reference to the relative proportions of the two red and white cell populations, the ABH blood group gene‐specified glycosyltransferase levels, and the HLA types. Expand
A true hermaphrodite chimera resulting from embryo amalgamation after in vitro fertilization.
High rates of successful pregnancy after in vitro fertilization depend on placing more than one embryo into the mother, a practice resulting in a 30-to-35-fold increase in dizygotic-twin deliveries, and the presence in a single person of cells derived from two or more zygotes is one such rare anomaly. Expand
Flow Cytometric Analyses of the Subclasses of Red Cell IgG Antibodies
Flow cytometric determination of IgG subclasses may be a useful tool in immunohematology, since subclass determinations were possible in all of these cases and offers the possibility of sufficient standardization. Expand
Anti‐D in a D‐positive renal transplant patient
The occurrence of anti‐D in a D‐positive renal transplant recipient without hemolysis, which is most likely attributable to microchimerism, is reported. Expand
Schanfield MS (1997) Anti-D in a D-positive renal transplant
  • patient. Transfusion
  • 1997