A disintegrin and metalloproteinase 15-mediated glycocalyx shedding contributes to vascular leakage during inflammation

@inproceedings{Yang2018ADA,
  title={A disintegrin and metalloproteinase 15-mediated glycocalyx shedding contributes to vascular leakage during inflammation},
  author={Xiaoyuan Yang and Jamie E Meegan and Melanie Jannaway and Danielle C Coleman and Sarah Y. Yuan},
  booktitle={Cardiovascular research},
  year={2018}
}
  • Xiaoyuan Yang, Jamie E Meegan, +2 authors Sarah Y. Yuan
  • Published in Cardiovascular research 2018
  • Medicine, Biology
  • Aims Endothelial hyperpermeability exacerbates multiple organ damage during inflammation or infection. The endothelial glycocalyx, a protective matrix covering the luminal surface of endothelial cells (ECs), undergoes enzymatic shedding during inflammation, contributing to barrier hyperpermeability. A disintegrin and metalloproteinase 15 (ADAM15) is a sheddase capable of cleaving the ectodomains of membrane-bound molecules. Herein, we tested whether and how ADAM15 is involved in glycocalyx… CONTINUE READING

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