A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.

@article{NyrenErickson2013ADA,
  title={A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.},
  author={Erin Kathryn Nyren-Erickson and John Michael Jones and Dharmendra K. Srivastava and Sanku Mallik},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1830 10},
  pages={
          4445-55
        }
}
BACKGROUND A disintegrin and metalloproteinase-12 (ADAM12) is a member of the greater ADAM family of enzymes: these are multifunctional, generally membrane-bound, zinc proteases for which there are forty genes known (21 of these appearing in humans). ADAM12 has been implicated in the pathogenesis of various cancers, liver fibrogenesis, hypertension, and asthma, and its elevation or decrease in human serum has been linked to these and other physiological/pathological conditions. SCOPE In this… CONTINUE READING
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