A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10.

  title={A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10.},
  author={Edward T. Parkin and Benjamin C Harris},
  journal={Journal of neurochemistry},
  volume={108 6},
A disintegrin and metalloproteinase (ADAM) 10 is a type I transmembrane glycoprotein responsible for the ectodomain shedding of a range of proteins including the amyloid precursor protein implicated in Alzheimer's disease. In this study we demonstrate that ADAM10 itself is subject to shedding by one or more ADAMs. Expression of epitope-tagged wild-type ADAM10 in SH-SY5Y cells enabled the detection of a soluble ectodomain in conditioned medium. Shedding of the ADAM10 ectodomain was inhibited by… CONTINUE READING


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Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme

  • C. Escrevente, V A.Morais, S. Keller, C M.Soares, P. Altevogt, J. Costa
  • Biochim. Biophys
  • 2008
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