A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.

  title={A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.},
  author={Amitabh Sharma and J{\"o}rg Menche and C. Chris Huang and Tatiana Ort and Xiaobo Zhou and Maksim Kitsak and Nidhi Sahni and Derek M Thibault and Linh Voung and Feng Guo and Susan Dina Ghiassian and Natali Gulbahce and Fr{\'e}d{\'e}ric Baribaud and Joel E. Tocker and Radu Dobrin and Elliot S. Barnathan and Hao Liu and Reynold A. Panettieri and Kelan G Tantisira and Weiliang Qiu and Benjamin A. Raby and Edwin K. Silverman and Marc Vidal and Scott T. Weiss and A L Barabasi},
  journal={Human molecular genetics},
  volume={24 11},
Recent advances in genetics have spurred rapid progress towards the systematic identification of genes involved in complex diseases. Still, the detailed understanding of the molecular and physiological mechanisms through which these genes affect disease phenotypes remains a major challenge. Here, we identify the asthma disease module, i.e. the local neighborhood of the interactome whose perturbation is associated with asthma, and validate it for functional and pathophysiological relevance… 

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