A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment.

@article{Shiran2003ADB,
  title={A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment.},
  author={Mohammad Reza Shiran and Joey Chowdry and Amin Rostami-Hodjegan and S Wynne Ellis and Martin S. Lennard and Mohammed Zafar Iqbal and Oldwale Lagundoye and Nicholas Seivewright and Geoffrey T. Tucker},
  journal={British journal of clinical pharmacology},
  year={2003},
  volume={56 2},
  pages={220-4}
}
AIMS To assess CYP2D6 activity and genotype in a group of patients undergoing methadone maintenance treatment (MMT). METHODS Blood samples from 34 MMT patients were genotyped by a polymerase chain reaction-based method, and results were compared with CYP2D6 phenotype (n = 28), as measured by the molar metabolic ratio (MR) of dextromethorphan (DEX)/dextrorphan (DOR) in plasma. RESULTS Whereas 9% of patients (3/34) were poor metabolizers (PM) by genotype, 57% (16/28) were PM by phenotype (P… CONTINUE READING

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