A disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells.

@article{Fuster2003ADP,
  title={A disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells.},
  author={Mark M. Fuster and Jillian R. Brown and Lianchun Wang and Jeffrey D Esko},
  journal={Cancer research},
  year={2003},
  volume={63 11},
  pages={2775-81}
}
Clustered presentation of sialyl Lewis X (sLe(X)) on tumor cell mucins is thought to facilitate metastasis through binding to selectin adhesion receptors expressed on platelets, leukocytes and endothelial cells. Thus, interfering with sLe(X) assembly might provide a chemotherapeutic method for treating metastatic disease. Prior studies have shown that peracetylated disaccharides can act in cells as substrates for the assembly of oligosaccharides related to sLe(X) synthesis, and the assembly of… CONTINUE READING