A directed screen for genes involved in Drosophila blood cell activation.

  title={A directed screen for genes involved in Drosophila blood cell activation.},
  author={Carl-Johan Zettervall and Ines Anderl and M J Williams and Ruth Palmer and {\'E}va Kurucz and Istv{\'a}n And{\'o} and Dan Hultmark},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 39},
An attack by a parasitic wasp activates a vigorous cellular immune response in Drosophila larvae. This response is manifested by an increased number of circulating cells, the hemocytes, and by the appearance of a specialized class of hemocyte, the lamellocytes, which participate in the encapsulation and killing of the parasite. To study the molecular mechanisms of this response, we have overexpressed different genes in the hemocytes, by using the GAL4-upstream activating sequence system and a… CONTINUE READING
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