A direct view of the complex multi-pathway folding of telomeric G-quadruplexes

@inproceedings{Aznauryan2016ADV,
  title={A direct view of the complex multi-pathway folding of telomeric G-quadruplexes},
  author={Mikayel Aznauryan and Siri S\ondergaard and Sofie L. Noer and Birgit Schi\ott and Victoria Birkedal},
  booktitle={Nucleic acids research},
  year={2016}
}
G-quadruplexes (G4s) are DNA secondary structures that are capable of forming and function in vivo The propensity of G4s to exhibit extreme polymorphism and complex dynamics is likely to influence their cellular function, yet a clear microscopic picture of their folding process is lacking. Here we employed single-molecule FRET microscopy to obtain a direct view of the folding and underlying conformational dynamics of G4s formed by the human telomeric sequence in potassium containing solutions… CONTINUE READING

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