A direct screen for c-di-GMP modulators reveals a Salmonella Typhimurium periplasmic ʟ-arginine–sensing pathway

@article{Mills2015ADS,
  title={A direct screen for c-di-GMP modulators reveals a Salmonella Typhimurium periplasmic ʟ-arginine–sensing pathway},
  author={Erez Mills and Erik Petersen and Bridget R. Kulasekara and Samuel I. Miller},
  journal={Science Signaling},
  year={2015},
  volume={8},
  pages={ra57-ra57}
}
Cyclic-di-GMP (c-di-GMP) is a bacterial second messenger that transduces internal and external signals and regulates bacterial motility and biofilm formation. Some organisms encode more than 100 c-di-GMP–modulating enzymes, but only for a few has a signal been defined that modulates their activity. We developed and applied a high-throughput, real-time flow cytometry method that uses a fluorescence resonance energy transfer (FRET)–based biosensor of free c-di-GMP to screen for signals that… CONTINUE READING
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