A direct role for dual oxidase in Drosophila gut immunity.

  title={A direct role for dual oxidase in Drosophila gut immunity.},
  author={E Ha and C Oh and Yun Soo Bae and Won-Jae Lee},
  volume={310 5749},
Because the mucosal epithelia are in constant contact with large numbers of microorganisms, these surfaces must be armed with efficient microbial control systems. Here, we show that the Drosophila nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme, dual oxidase (dDuox), is indispensable for gut antimicrobial activities. Adult flies in which dDuox expression is silenced showed a marked increase in mortality rate even after a minor infection through ingestion of microbe… CONTINUE READING
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