A direct role for C1 inhibitor in regulation of leukocyte adhesion.

@article{Cai2005ADR,
  title={A direct role for C1 inhibitor in regulation of leukocyte adhesion.},
  author={Shenghe Cai and Vandana S. Dole and Wolfgang Bergmeier and Jennifer Scafidi and Hanping Feng and Denisa D Wagner and Alvin E. Davis},
  journal={Journal of immunology},
  year={2005},
  volume={174 10},
  pages={6462-6}
}
Plasma C1 inhibitor (C1INH) is a natural inhibitor of complement and contact system proteases. Heterozygosity for C1INH deficiency results in hereditary angioedema, which is mediated by bradykinin. Treatment with plasma C1INH is effective not only in patients with hereditary angioedema, but also in a variety of other disease models, in which such therapy is accompanied by diminished neutrophil infiltration. The underlying mechanism has been explained primarily as a result of the inhibition of… CONTINUE READING

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