A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation.

@article{Herrera1989ADR,
  title={A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation.},
  author={Ricardo Garc{\'i}a Herrera and H S Ro and Gregory S. Robinson and Kleanthis G. Xanthopoulos and Bruce M. Spiegelman},
  journal={Molecular and cellular biology},
  year={1989},
  volume={9 12},
  pages={5331-9}
}
Adipocyte differentiation is accompanied by the transcriptional activation of many new genes, including the gene encoding adipocyte P2 (aP2), an intracellular lipid-binding protein. Using specific deletions and point mutations, we have shown that at least two distinct sequence elements in the aP2 promoter contribute to the expression of the chloramphenicol acetyltransferase gene in chimeric constructions transfected into adipose cells. An AP-I site at -120, shown earlier to bind Jun- and Fos… CONTINUE READING

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