A direct method for the N-tetraalkylation of azamacrocycles

Abstract

An efficient protocol for the direct synthesis of N-tetraalkylated derivatives of the azamacrocycles cyclam and cyclen has been developed, using a partially miscible aqueous-organic solvent system with propargyl bromide, benzyl bromide, and related halides. The method works most effectively when the reaction mixture is shaken, not stirred. A crystal… (More)
DOI: 10.3762/bjoc.12.239

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