A direct estimate of the human alphabeta T cell receptor diversity.

Abstract

Generation and maintenance of an effective repertoire of T cell antigen receptors are essential to the immune system, yet the number of distinct T cell receptors (TCRs) expressed by the estimated 10(12) T cells in the human body is not known. In this study, TCR gene amplification and sequencing showed that there are about 10(6) different beta chains in the… (More)

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Cite this paper

@article{Arstila1999ADE, title={A direct estimate of the human alphabeta T cell receptor diversity.}, author={T. Petteri Arstila and Armanda Casrouge and V{\'e}ronique T Baron and J Even and Jean M. Kanellopoulos and P. Kourilsky}, journal={Science}, year={1999}, volume={286 5441}, pages={958-61} }