A direct comparison of the brain uptake and plasma clearance of N-[11C]methylspiroperidol and [18F]N-methylspiroperidol in baboon using PET.

Serial PET studies of N-[11C]methylspiroperidol and [18F]N-methylspiroperidol were carried out in a single baboon with an intervening time period of 2 h between injection of the 11C and the 18F-labeled tracers. The kinetic patterns of uptake and egress of radioactivity in striatum and cerebellum as well as the magnitude of the uptake was very similar with… CONTINUE READING