A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis.

  title={A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis.},
  author={Masahiko Kuroda and Kosuke Oikawa and Tetsuya Ohbayashi and Keiichi Yoshida and Kazuhiko Yamada and Junsei Mimura and Yoichi Matsuda and Yoshiaki Fujii-Kuriyama and Kiyoshi Mukai},
  journal={FEBS letters},
  volume={579 1},
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an endocrine disruptor that produces a variety of toxic effects. We have isolated a mouse homolog of the hWAPL gene, termed mouse WAPL (mWAPL), as a target of TCDD by cDNA representational difference analysis from mouse embryonic stem cells. A statistically significant increase in mWAPL expression was observed at 0.1 microM TCDD in AhR-/- mouse embryonic fibroblast cells. Interestingly, at 1 microM TCDD, mWAPL mRNA levels decreased in AhR+/+ cells… CONTINUE READING


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