A dimorphic pheromone circuit in Drosophila from sensory input to descending output

@article{Ruta2010ADP,
  title={A dimorphic pheromone circuit in Drosophila from sensory input to descending output},
  author={Vanessa Ruta and Sandeep Robert Datta and Maria Lu{\'i}sa Vasconcelos and J. W. Freeland and Loren L. Looger and Richard Axel},
  journal={Nature},
  year={2010},
  volume={468},
  pages={686-690}
}
Drosophila show innate olfactory-driven behaviours that are observed in naive animals without previous learning or experience, suggesting that the neural circuits that mediate these behaviours are genetically programmed. Despite the numerical simplicity of the fly nervous system, features of the anatomical organization of the fly brain often confound the delineation of these circuits. Here we identify a neural circuit responsive to cVA, a pheromone that elicits sexually dimorphic behaviours. We… 
Neural Circuits Underlying Mating Behavior in Drosophila
TLDR
The neural circuits underlying mating behavior in the fruit fly Drosophila melanogaster are investigated, leading to a novel model of decision-making that supports a model in which the balance of excitatory and inhibitory inputs onto central courtship-promoting neurons regulates the decision to court.
Dedicated olfactory neurons mediating attraction behavior to ammonia and amines in Drosophila
TLDR
A functionally segregated population of olfactory sensory neurons (OSNs) and projection neurons (PNs) in Drosophila melanogaster that are highly specific to ammonia and amines, which act as potent attractants is described.
Olfactory responses of Drosophila are encoded in the organization of projection neurons
TLDR
The findings suggest that before neural computation in the inner brain, some of the olfactory information are already encoded in the spatial organization of uPNs, illuminating that a certain degree of labeled-line strategy is at work in the Drosophila Olfactory system.
Motor Neurons Controlling Fluid Ingestion in Drosophila melanogaster
TLDR
This thesis describes the identification of motor neurons that innervate the proboscis musculature of Drosophila and describes a population of neurons whose morphology suggests they may receive input from sensory taste neurons.
The neuropeptide tachykinin is essential for pheromone detection in a gustatory neural circuit
TLDR
A neuropeptide-modulated central brain circuit in Drosophila that underlies the programmed behavioral response to a gustatory sex pheromone is described and will allow further examination of the molecular basis by which innate behaviors are modulated by gustatory cues and physiological state.
A distributed dopamine-gated circuit underpins reproductive state-dependent behavior in Drosophila females
TLDR
The data in the fly suggests that reproductive state-dependent expression of female choice behavior is regulated by a dopamine-gated distributed learning circuit comprising both higher olfactory brain centers.
Olfactory processing in the lateral horn of Drosophila
TLDR
This review will summarize the recent advances in mapping and characterizing LH-specific cell types, their functional properties with respect to odor tuning, their neurotransmitter profiles, their connectivity to pre- synaptic and post-synaptic partner neurons as well as their impact for olfactory behavior as known so far.
Excitation and inhibition onto central courtship neurons biases Drosophila mate choice
TLDR
Central neural pathways in the male brain that process female and male pheromones are examined to demonstrate that the balance of excitatory and inhibitory drives onto central courtship-promoting neurons controls mating decisions.
...
...

References

SHOWING 1-10 OF 34 REFERENCES
The Drosophila pheromone cVA activates a sexually dimorphic neural circuit
TLDR
A neural tracing procedure that employs two-photon laser scanning microscopy to activate the photoactivatable green fluorescent protein is developed, showing that the projections from the DA1 glomerulus to the protocerebrum are sexually dimorphic.
Fruitless specifies sexually dimorphic neural circuitry in the Drosophila brain
TLDR
A subset of fru-expressing interneurons in the brain that show marked sexual dimorphism in their number and projection pattern are identified and demonstrated, suggesting that Fru ‘masculinizes’ certain neurons, thereby establishing neural substrates for male-typical behaviour.
The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster Meigen.
TLDR
The data suggest that the mushroom body may not by itself be a "center" for learning and memory, but that it can equally be considered as a preprocessor of olfactory signals en route to "higher" protocerebral regions.
Identification of an aggression-promoting pheromone and its receptor neurons in Drosophila
TLDR
It is shown that 11-cis-vaccenyl acetate (cVA), a male-specific volatile pheromone, robustly promotes male–male aggression in the vinegar fly Drosophila melanogaster, indicating that cVA may mediate negative-feedback control of male population density, through its effect on aggression.
...
...