A dimerization-dependent mechanism drives RAF catalytic activation

@article{Rajakulendran2009ADM,
  title={A dimerization-dependent mechanism drives RAF catalytic activation},
  author={Thanashan Rajakulendran and Malha Sahmi and Martin Lefrançois and Frank Sicheri and Marc Therrien},
  journal={Nature},
  year={2009},
  volume={461},
  pages={542-545}
}
The ERK (extracellular signal-regulated kinase) pathway is an evolutionarily conserved signal transduction module that controls cellular growth, differentiation and survival. [...] Key Result Here, using Drosophila Schneider S2 cells, we demonstrate that RAF catalytic function is regulated in response to a specific mode of dimerization of its kinase domain, which we term the side-to-side dimer.Expand
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