A dimeric peptide that binds selectively to prostate-specific membrane antigen and inhibits its enzymatic activity.

@article{Aggarwal2006ADP,
  title={A dimeric peptide that binds selectively to prostate-specific membrane antigen and inhibits its enzymatic activity.},
  author={Saurabh Aggarwal and P Vishwanath Singh and Ozlem Topaloglu and John T Isaacs and Samuel R Denmeade},
  journal={Cancer research},
  year={2006},
  volume={66 18},
  pages={
          9171-7
        }
}
Prostate-specific membrane antigen (PSMA) is highly expressed by both normal and malignant prostate epithelial cells and by the neovasculature of many tumor types; however, it is not expressed by normal endothelial cells or other normal tissues. PSMA, therefore, represents an attractive candidate for selectively targeted therapies for prostate and/or other solid tumors. As an alternative approach to antibody-based anti-PSMA therapies, small peptides that bind selectively to PSMA-producing cells… CONTINUE READING

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  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 1 EXCERPT

- specific membrane antigen

DM Nanus, MI Milowsky, L Kostakoglu
  • 2004

- specific membrane antigen ( PSMA ) versus a prostate - specific membrane antigen - like gene

AC Cunha, B Weigle, A Kiessling
  • 2004

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