A dimension reduction approach for modeling multi-locus interaction in case-control studies.

@article{Basu2011ADR,
  title={A dimension reduction approach for modeling multi-locus interaction in case-control studies.},
  author={Saonli Basu and Wei Pan and William S Oetting},
  journal={Human heredity},
  year={2011},
  volume={71 4},
  pages={234-45}
}
Studying one locus or one single nucleotide polymorphism (SNP) at a time may not be sufficient to understand complex diseases because they are unlikely to result from the effect of only one SNP. Each SNP alone may have little or no effect on the risk of the disease, but together they may increase the risk substantially. Analyses focusing on individual SNPs… CONTINUE READING