A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR.

@article{Yang2003ADS,
  title={A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR.},
  author={Di Yang and Michel F{\'e}l{\'e}tou and Nigel R Levens and Ji Nan Zhang and Paul Michel Vanhoutte},
  journal={Hypertension},
  year={2003},
  volume={41 1},
  pages={143-8}
}
A modified bioassay system was designed to demonstrate the diffusible nature of endothelium-derived contracting factor(s) released by acetylcholine in the aorta of spontaneously hypertensive rat. In "sandwich"-like layered preparation, isometric tension was recorded from a bioassay strip (without endothelium) in the presence of N(G)-nitro-L-arginine and tetrahydrobiopterin to selectively potentiate endothelium-dependent contractions. A donor strip (with or without endothelium) was stitched on… CONTINUE READING

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