A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation.

@article{Soulet2005ADR,
  title={A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation.},
  author={Carine Soulet and B{\'e}atrice Hechler and M-P Gratacap and Monique Plantavid and Stefan Offermanns and Christian Gachet and Bernard Payrastre},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2005},
  volume={3 10},
  pages={2296-306}
}
The dynamics of the actin cytoskeleton, largely controlled by the Rho family of small GTPases (Rho, Rac and Cdc42), is critical for the regulation of platelet responses such as shape change, adhesion, spreading and aggregation. Here, we investigated the role of adenosine diphosphate (ADP), a major co-activator of platelets, on the activation of Rac. ADP rapidly activated Rac in a dose-dependent manner and independently of GPIIb/IIIa and phosphoinositide 3-kinase. ADP alone, used as a primary… CONTINUE READING