A differential response to newt regeneration extract by C2C12 and primary mammalian muscle cells

@inproceedings{Kawesa2015ADR,
  title={A differential response to newt regeneration extract by C2C12 and primary mammalian muscle cells},
  author={Sarah Kawesa and Jason R Vanstone and Catherine Tsilfidis},
  booktitle={Skeletal Muscle},
  year={2015}
}
Dedifferentiation, a process whereby differentiated cells lose their specialized characteristics and revert to a less differentiated state, plays a key role in the regeneration process in urodele amphibians such as the red spotted newt, Notophthalmus viridescens. Dedifferentiation of fully mature tissues is generally absent in mammalian cells. Previous studies have shown that mouse C2C12 multinucleated myotubes treated with extract derived from regenerating newt forelimbs can re-enter the cell… CONTINUE READING
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