A different genetic code in human mitochondria

@article{Barrell1979ADG,
  title={A different genetic code in human mitochondria},
  author={B. Barrell and A. Bankier and J. Drouin},
  journal={Nature},
  year={1979},
  volume={282},
  pages={189-194}
}
Comparison of the human mitochrondrial DNA sequence of the cytochrome oxidase subunit II gene and the sequence of the corresponding beef heart protein shows that UGA is used as a tryptophan codon and not as a termination codon and suggests that AU A may be a methionine and not an isoleucine codon. The cytochrome oxidase II gene is contiguous at its 5′ end with a tRNAAsp gene and there are only 25 bases at its 3′ end before a tRNALys gene. These tRNAs are different from all other known tRNA… Expand
444 Citations
Sequence and organization of the human mitochondrial genome
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