A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice.

@article{Frey1996ADF,
  title={A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice.},
  author={Uwe Frey and Matthias M{\"u}ller and Dietmar Kuhl},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 6},
  pages={2057-63}
}
The establishment of hippocampal long-term (LTP) requires protein and mRNA synthesis, suggesting that neuronal activity resulting in LTP initiates a cascade of gene expression. The expression of the gene for the extracellular serine protease tissue plasminogen activator (t-PA) is induced during LTP. Here we analyze long-lasting LTP (L-LTP,>4 hr)in CA1 hippocampal slices of mice homozygous for disrupted t-PA genes. Although mutant mice appear to exhibit long-term potentiation, we provide… CONTINUE READING
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Modulatory effect of plasminogen on NMDA-induced increase in intracellular free calcium concentration in rat cultured hippocampal neurons

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Does the late maintenance

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Does the late maintenance of CAl - LTP depend on GABAergic inhibition ?

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