A dietary fatty acid counteracts neuronal mechanical sensitization

@article{Romero2020ADF,
  title={A dietary fatty acid counteracts neuronal mechanical sensitization},
  author={Luis O. Romero and R. Caires and A. Nickolls and Alexander T. Chesler and J. Cordero-Morales and V. V{\'a}squez},
  journal={Nature Communications},
  year={2020},
  volume={11}
}
PIEZO2 is the essential transduction channel for touch discrimination, vibration, and proprioception. Mice and humans lacking Piezo2 experience severe mechanosensory and proprioceptive deficits and fail to develop tactile allodynia. Bradykinin, a proalgesic agent released during inflammation, potentiates PIEZO2 activity. Molecules that decrease PIEZO2 function could reduce heightened touch responses during inflammation. Here, we find that the dietary fatty acid margaric acid (MA) decreases… Expand

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