A dietary enzyme: alpha-methylacyl-CoA racemase/P504S is overexpressed in colon carcinoma.

@article{Jiang2003ADE,
  title={A dietary enzyme: alpha-methylacyl-CoA racemase/P504S is overexpressed in colon carcinoma.},
  author={Zhong Yi Jiang and Gary R Fanger and Barbara F. Banner and Bruce A. Woda and Paul Algate and Karen Dresser and Jiangchun Xu and Steven G Reed and Kenneth L. Rock and Peiguo G. Chu},
  journal={Cancer detection and prevention},
  year={2003},
  volume={27 6},
  pages={422-6}
}
Epidemiological studies have shown that consumption of red meat increases the risk of developing colon cancer. An enzyme, alpha-methylacyl CoA racemase (AMACR), also known as P504S, plays an important role in peroxisomal beta-oxidation of branched-chain fatty acids from red meat and dairy products. High expression of AMACR was recently found in prostate cancer. In this study, we investigated expression of AMACR in 242 cases of colonic tumors including 176 colorectal carcinomas, 38 colon… CONTINUE READING

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