A diastereoselective one-pot, three-step cascade toward α-substituted allylboronic esters.

Abstract

A new highly diastereoselective synthesis of chiral α-substituted allylboronic esters, based on a one-pot, three-step cascade, is presented. The palladium- and acid-cocatalyzed reaction cascade involves a desilylation of a TBS-protected allylic alcohol, borylation, and addition of an allyl group to an aldehyde. Herein we present the first application of a… (More)
DOI: 10.1021/jo5004168

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