A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis.

@article{Zhang2012ADB,
  title={A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis.},
  author={Jing Zhang and Susobhan Sarkar and Rowena C Cua and Yan Zhou and Walter J. Hader and V. Wee Yong},
  journal={Carcinogenesis},
  year={2012},
  volume={33 2},
  pages={312-9}
}
Glioma cells in situ are surrounded by microglia, suggesting the potential of glioma-microglia interactions to produce various outcomes. As chemokines are important mediators of cell-cell communication, we sought first to identify commonly expressed chemokines in 16 human glioma lines. We found CCL2 (macrophage chemoattractant protein-1) messenger RNA to be expressed by the majority of glioma lines. However, these lines did not express the CCL2 receptor, CCR2, which was found on microglia. Next… CONTINUE READING
48 Citations
48 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

/ macrophages promote glioma progression

  • I. Bettinger
  • Microglia
  • 2011

Expression of the new CXCL 12 receptor , CXCR 7 , in gliomas

  • C. Rolhion
  • Cancer Biol . Ther .
  • 2011

compared with leukocytes and they regulate cytokine levels in activated microglia

  • D. S. Markovic
  • 2011

CXCL 12 ( SDF - 1 ) / CXCR 4 pathway in cancer

  • B. A. Teicher
  • Clin . Cancer Res .
  • 2010

Similar Papers

Loading similar papers…