A diacidic motif determines unconventional secretion of wild-type and ALS-linked mutant SOD1

@inproceedings{CruzGarcia2017ADM,
  title={A diacidic motif determines unconventional secretion of wild-type and ALS-linked mutant SOD1},
  author={David Cruz-Garcia and Nathalie Brouwers and Juan M. Duran and Gabriel Mora and Amy J Curwin and Vivek Malhotra},
  booktitle={The Journal of cell biology},
  year={2017}
}
The nutrient starvation-specific unconventional secretion of Acb1 in Saccharomyces cerevisiae requires ESCRT-I, -II, and -III and Grh1. In this study, we report that another signal sequence lacking cytoplasmic protein, superoxide dismutase 1 (SOD1), and its mutant form linked to amyotrophic lateral sclerosis (ALS), is also secreted by yeast upon nutrient starvation in a Grh1- and ESCRT-I-, -II-, and -III-dependent process. Our analyses reveal that a conserved diacidic motif (Asp-Glu) in these… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 17 times over the past 90 days. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 37 references

ESC RT - III drives the final stages of CUPS maturation for unconventional protein secretion

  • A. J. Curwin, M. N. Brouwers, D. Teis Alonso Y Adell, S. Parashuraman G. Turacchio, P. Ronchi, V. Malhotra
  • eLife .
  • 2016
Highly Influential
15 Excerpts

Similar Papers

Loading similar papers…