A developmentally regulated GAGA box-binding factor and Sp1 are required for transcription of the hsp70.1 gene at the onset of mouse zygotic genome activation.

@article{Bevilacqua2000ADR,
  title={A developmentally regulated GAGA box-binding factor and Sp1 are required for transcription of the hsp70.1 gene at the onset of mouse zygotic genome activation.},
  author={Arturo Bevilacqua and Maria Teresa Fiorenza and F. J. C. Mangia},
  journal={Development},
  year={2000},
  volume={127 7},
  pages={1541-51}
}
We have investigated the onset of zygotic genome transcription in early two-cell mouse embryos by analyzing the regulation of hsp70.1, one of the first genes expressed after fertilization. The transcriptional activation of both an episomic hsp70 promoter and the endogenous hsp70.1 gene requires the contiguity of the GC box proximal to the TATA box with a GAGA box and involves GC box- and GAGA box-binding factors. In vivo transcription factor titrations with double-stranded… CONTINUE READING
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by transcription factor Sp1

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  • Nucleic Acids Res
  • 1995
Highly Influential
6 Excerpts

and its expression in mouse cell lines

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1 Excerpt

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