A developmental timing microRNA and its target regulate life span in C. elegans.

Abstract

The microRNA lin-4 and its target, the putative transcription factor lin-14, control the timing of larval development in Caenorhabditis elegans. Here, we report that lin-4 and lin-14 also regulate life span in the adult. Reducing the activity of lin-4 shortened life span and accelerated tissue aging, whereas overexpressing lin-4 or reducing the activity of… (More)

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Cite this paper

@article{Boehm2005ADT, title={A developmental timing microRNA and its target regulate life span in C. elegans.}, author={Michelle Boehm and Frank J. Slack}, journal={Science}, year={2005}, volume={310 5756}, pages={1954-7} }