A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs.

  title={A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs.},
  author={Tae-Min Kim and Wei Huang and Richard Chan Woo Park and Peter J. Park and Mark D. Johnson},
  journal={Cancer research},
  volume={71 9},
mRNA expression profiling has suggested the existence of multiple glioblastoma subclasses, but their number and characteristics vary among studies and the etiology underlying their development is unclear. In this study, we analyzed 261 microRNA expression profiles from The Cancer Genome Atlas (TCGA), identifying five clinically and genetically distinct subclasses of glioblastoma that each related to a different neural precursor cell type. These microRNA-based glioblastoma subclasses displayed… CONTINUE READING
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