A developmental switch in B lymphopoiesis.

  title={A developmental switch in B lymphopoiesis.},
  author={R. Hardy and K. Hayakawa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={88 24},
  • R. Hardy, K. Hayakawa
  • Published 1991
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • B and T lymphocytes are generated from hematopoietic stem cells during both fetal and adult life. A critical unresolved issue is whether the differentiation pathways in lymphopoiesis are the same in fetal and adult animals or whether they differ, similar to the hemoglobin switch in erythropoiesis. We report here that a developmental switch occurs in B lymphopoiesis. We isolated "pro-B" cells (i.e., cells that have initiated, but not completed, heavy-chain gene rearrangement) from fetal and… CONTINUE READING
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