A detailed linkage map of subtelomeric murine Chromosome 12 region including the situs inversus mutation locus IV

@article{Meeus1992ADL,
  title={A detailed linkage map of subtelomeric murine Chromosome 12 region including the situs inversus mutation locus IV},
  author={Anne de Meeus and Sandrine Alonso and Jacques Demaille and Patrice Bouvagnet},
  journal={Mammalian Genome},
  year={1992},
  volume={3},
  pages={637-643}
}
A mouse model is an invaluable tool to tackle genesis of human congenital diseases that have so far eluded human studies. Homozygote for the iv mutation, the murine Si/Col strain presents a left-right lateralization defect of thoracic and abdominal organs and heart defects very similar to human ones. This iv mutation has been mapped to the region between the Aat and Igh-C loci, suggesting the presence of an equivalent human gene in the human syntenic 14q3 region. A precise linkage map of the… CONTINUE READING

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ChestIs associated anatomic site ofCongenital Heart Defects
Homozygote for the iv mutation , the murine Si / Col strain presents a left - right lateralization defect of thoracic and abdominal organs and heart defects very similar to human ones .
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