A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene.

@article{Bodenner1991ADF,
  title={A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene.},
  author={Donald L Bodenner and M A Mroczynski and Bruce D. Weintraub and Sally Radovick and Fredric E. Wondisford},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 32},
  pages={21666-73}
}
The first exon of the human thyrotropin-beta (hTSH beta) gene has been demonstrated in our laboratory to contain a major thyroid hormone inhibitory element. In order to characterize fully this element, we have performed a detailed functional and structural scanning mutational analysis of this element. Various -1192 to +37 (base pairs) bp fragments of the hTSH beta gene containing consecutive five deoxythymidine substitution mutations of the first exon were inserted into a luciferase reporter… CONTINUE READING

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