A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.

@article{Takacs2009ADL,
  title={A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.},
  author={Zoltan Takacs and Megan Toups and Astrid Kollewe and Erik A. Johnson and Luis G Cuello and Gr{\'e}gory Driessens and Matthew Biancalana and Akiko Koide and Cristiano Gonçalves Ponte and Eduardo Perozo and Thomas F Gajewski and Guilherme Suarez-Kurtz and Shohei Koide and Steve An Goldstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 52},
  pages={22211-6}
}
Venomous animals immobilize prey using protein toxins that act on ion channels and other targets of biological importance. Broad use of toxins for biomedical research, diagnosis, and therapy has been limited by inadequate target discrimination, for example, among ion channel subtypes. Here, a synthetic toxin is produced by a new strategy to be specific for human Kv1.3 channels, critical regulators of immune T cells. A phage display library of 11,200 de novo proteins is designed using the alpha… CONTINUE READING