A designed functional metalloenzyme that reduces O2 to H2O with over one thousand turnovers.

Abstract

Much progress has been made in designing metalloproteins with structures similar to native enzymes and advances in computational biology have allowed for rational design of enzyme function as well. Despite these achievements, most designed enzymes have simple active site structures and low activities, with limited turnover numbers. Designing artificial… (More)
DOI: 10.1002/anie.201201981

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Cite this paper

@article{Miner2012ADF, title={A designed functional metalloenzyme that reduces O2 to H2O with over one thousand turnovers.}, author={Kyle D. Miner and Arnab Mukherjee and Yi-Gui Gao and Eric L. Null and Igor D. Petrik and Xuan Zhao and N. H. Yeung and Howard Robinson and Yi Lu}, journal={Angewandte Chemie}, year={2012}, volume={51 23}, pages={5589-92} }