A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma.

@article{Begg2006ADF,
  title={A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma.},
  author={Colin B. Begg and Amanda J. Hummer and Urvi J. Mujumdar and Bruce Konrad Armstrong and Anne Kricker and Loraine D. Marrett and Robert C. Millikan and Stephen B. Gruber and Hoda Anton Culver and R. A. Zanetti and Richard P. Gallagher and Terrence X Dwyer and Timothy R. Rebbeck and Klaus J. Busam and Lynn From and Marianne Berwick},
  journal={International journal of epidemiology},
  year={2006},
  volume={35 3},
  pages={756-64}
}
BACKGROUND The population-based case-control study is not suited to the evaluation of rare genetic (or environmental) factors. The use of a novel case-control design in which cases have second primaries and controls are cancer survivors has been proposed for this purpose. METHODS We report results from an international study of melanoma that involved population-based ascertainment of incident cases of second or subsequent primary melanoma as the 'case' group and incident cases of first… CONTINUE READING

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