A dermal HOX transcriptional program regulates site-specific epidermal fate.

  title={A dermal HOX transcriptional program regulates site-specific epidermal fate.},
  author={John L Rinn and Jordon K. Wang and Nancy C. Allen and Samantha A Brugmann and Amanda J Mikels and Helen K. Liu and Todd W Ridky and Hannes Stadler and Roeland Nusse and J A Helms and Howard Y Chang},
  journal={Genes & development},
  volume={22 3},
Reciprocal epithelial-mesenchymal interactions shape site-specific development of skin. Here we show that site-specific HOX expression in fibroblasts is cell-autonomous and epigenetically maintained. The distal-specific gene HOXA13 is continually required to maintain the distal-specific transcriptional program in adult fibroblasts, including expression of WNT5A, a morphogen required for distal development. The ability of distal fibroblasts to induce epidermal keratin 9, a distal-specific gene… CONTINUE READING

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