A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs.

@article{Schul2007ADF,
  title={A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs.},
  author={Wouter Schul and Wei Liu and Han-jin Xu and Michel Flamand and Subhash G. Vasudevan},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={195 5},
  pages={
          665-74
        }
}
Dengue fever is an emerging arboviral disease for which no vaccine or antiviral treatment exists and that causes thousands of fatalities each year. To develop an in vivo test system for antidengue drugs, AG129 mice, which are deficient for the interferon- alpha / beta and - gamma receptors, were injected with unadapted dengue virus, resulting in a dose-dependent transient viremia lasting several days and peaking on day 3 after infection. Additionally, nonstructural protein 1, increased levels… CONTINUE READING

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