A dendritic thioester hydrogel based on thiol-thioester exchange as a dissolvable sealant system for wound closure.

@article{Ghobril2013ADT,
  title={A dendritic thioester hydrogel based on thiol-thioester exchange as a dissolvable sealant system for wound closure.},
  author={Cynthia Ghobril and Kristie Charoen and Edward K Rodriguez and Ara Nazarian and Mark W. Grinstaff},
  journal={Angewandte Chemie},
  year={2013},
  volume={52 52},
  pages={
          14070-4
        }
}
A dissolvable dendritic thioester hydrogel based on thiol-thioester exchange for wound closure is reported. The hydrogel sealant adheres strongly to tissues, closes an ex vivo vein puncture, and withstands high pressures placed on a wound. The hydrogel sealant can be completely washed off upon exposure to thiolates based on thiol-thioester exchange and allow gradual wound re-exposure during definitive surgical care. 

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