A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma.

Abstract

Renal cell carcinoma (RCC) is resistant to chemo-therapy partly due to the overexpression of the P-glycoprotein. Several tumor suppressor genes have been reported to be silenced by hypermethylation of the promoter region in RCC. We recently reported that the in vitro cytotoxicity of vinblastine (VBL) was enhanced by pre-treatment with the demethylating… (More)
DOI: 10.3892/ijo.2011.999

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